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KMID : 0191119990140020223
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Journal of Korean Medical Science
1999 Volume.14 No. 2 p.223 ~ p.226
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Extramammary Paget´s disease with aggressive behavior: a report of two cases
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Kim JC
Kim HC/Jeong CS/Cho MK/Koh KS/Gong G/Koh JK/Lee MG
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Abstract
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Extramammary Paget's disease (EMPD) is an intraepithelial neoplastic disorder which is included as a rare malignant condition. However, it sometimes shows aggressive behavior of local recurrence and coexisting malignancy. We had experienced nine cases of EMPD involving the scrotum for seven years. Two cases of them presented metastasis. The first case presented extensive inguinal lymph node metastasis with underlying adnexal adenocarcinoma one year after wide local excision. The second case initially presented multiple metastasis to the liver and in the lymph node. The latter, showing fulminant progression with liver metastasis, may be only the second case reported in English literature. EMPD is considered as a malignant neoplasm with aggressive behavior from initial presentation. Because wide local excision of the lesion alone may be occasionally insufficient, a careful follow-up must be done to detect recurrence or internal malignancy.
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